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KMID : 0043320040270111183
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Archives of Pharmacal Research
2004 Volume.27 No. 11 p.1183 ~ p.1187
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Crosslinking of β-Cyclodextrin on Cholesterol Removal from Milk
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Kim S.H.
Ahn J.
Kwak H.S.
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Abstract
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This study was designed to develop crosslinking of -cyclodextrin (-CD), and determine the optimum conditions of different factors (mixing time, mixing temperature, and mixing speed) on cholesterol reduction from milk. Crosslinked -CD was prepared with epichlorohydrin. When milk was treated with different conditions, the cholesterol removal rate was in the range of 79.4 to 83.3% with 1 % crosslinked -CD addition, which were not significantly different among treatments. After cholesterol removal from milk, the used crosslinked -CD was washed for cholesterol dissociation and reused. For recycling study, the cholesterol removal rate in first trial was 81.8%, which was mostly same as that using new crosslinked -CD. With five trials repeatedly using the same sample, the mean cholesterol removal rate was 81.2%. The present study indicated that the optimum conditions on cholesterol removal using crosslinked -CD were 10 min mixing with 400 rpm speed at with about 80% cholesterol removal. In addition, crosslinked -CD resulted in the effective recycling efficiency almost 100%.
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KEYWORD
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Crosslinked β-CD, Cholesterol removal, Milk, Recycling
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